Authors
Aleksandra Köhler, Bowang Chen, Federica Gemignani, Rossella Elisei, Cristina Romei, Gisella Figlioli, Monica Cipollini, Alfonso Cristaudo, Franco Bambi, Per Hoffmann, Stefan Herms, Michał Kalemba, Dorota Kula, Shelley Harris, Peter Broderick, Richard Houlston, Susana Pastor, Ricard Marcos, Antonia Velázquez, Barbara Jarząb, Kari Hemminki, Stefano Landi, Asta Försti
Publication date
2013/10/1
Journal
The Journal of Clinical Endocrinology & Metabolism
Volume
98
Issue
10
Pages
E1674-E1681
Publisher
Oxford University Press
Description
Context
Genome-wide association studies (GWASs) of differentiated thyroid cancer (DTC) have identified associations with polymorphisms at 2q35 (DIRC3), 8p12 (NRG1), 9q22.33 (FOXE1), and 14q13.2 (NKX2-1). However, most of the inherited genetic risk factors of DTC remain to be discovered.
Objective
Our objective was to identify additional common DTC susceptibility loci.
Design
We conducted a GWAS in a high-incidence Italian population of 690 cases and 497 controls and followed up the most significant polymorphisms in 2 additional Italian series and in 3 low-incidence populations totaling 2958 cases and 3727 controls.
Results
After excluding the most robust previously identified locus (9q22.33), the strongest association was shown by rs6759952, confirming the recently published association in DIRC3 (odds ratio [OR] = 1 …
Total citations
Scholar articles
A Köhler, B Chen, F Gemignani, R Elisei, C Romei… - The Journal of Clinical Endocrinology & Metabolism, 2013